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KMID : 0363220130510050360
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Korean Journal of Dermatology
2013 Volume.51 No. 5 p.360 ~ p.363
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Circumscribed Acral Hypokeratosis with Expression of Human Papillomavirus High-risk Type 16, 18
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Lee Hye-Young
Kim Jun-Ki
Lee Ji-Yeoun
Yoon Tae-Young
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Abstract
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Circumscribed acral hypokeratosis (CAH) is a rare disorder characterized by a well-circumscribed and erythematous depressed patch on the palm or sole. It usually presents as an asymptomatic, solitary, long-standing lesion in middle-aged to elderly women. Histologically, it has a characteristic stair-like configuration between normal and involved skin with an abrupt thinning of the horny layer and a decreased granular layer. Although the pathogenesis of CAH is not well established, several hypotheses were proposed. To our knowledge, there have been only two cases to document HPV in a single lesion of CAH. Herein, we report the third case of circumscribed acral hypokeratosis with expression of human papillomavirus, high-risk type 16, 18.
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KEYWORD
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Circumscribed acral hypokeratosis, Human papilloma virus
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